The influence of resistant force equations and coupling system on long train dynamics simulations

In the simulation of the longitudinal dynamics of long trains, the modeling of the resistant forces and of the coupling system are two essential aspects. The modeling of the resistant forces directly affects the speed reached by each vehicle as well as the in-train forces. A literature review witnesses different laws for the calculation of both ordinary and accidental resistances. One of the objectives of this paper is to evaluate from the numerical point of view the influence of the resistant forces modeling strategy on the simulation outputs, i.e., on the speeds and in-train forces, by comparing different laws for propulsion and curving resistances. For what concerns the connection between the vehicles of the train, it is well known that the connection system is of utmost importance for the safety and running stability of the train. In this paper, the two existing coupling systems, i.e., the European buffer-hook system and the coupler used outside the European continent are first described, both in terms of operation and modelling techniques, and then they are compared on the same simulation scenario. All the simulations are performed on the first scenario of the International benchmark of the longitudinal train dynamic simulators, using the LTDPoliTO code developed by the railway research team from Politecnico di Torino

A 2000 Year-Old Cold Case: the Violent Death of a Roman Mariner Between Archaeology and Forensic Anthropology.

During archaeological excavation of the Roman port of Pisa in 1999, two skeletons came to light, laden down by a Roman ship, sunk and partly preserved, probably caused by a disastrous flood in the River Auser. Skeletons belonging to an adult male and a small dog, resembling the present Dachshund breed, were recovered. The canine rested on he man's left upper limb at the forearm level. This 2000 year-old cold case has been investigated using physical and forensic anthropological techniques which allowed us to define the biological profile of this subject: including the sex, age, height and skeletal pathology. The taphonomic analysis of bones and the context as a possible crime scene let us understand the decomposition and death dynamics revealing the causes of the partial dismemberment. The case presented is an example the physical anthropology as a discipline useful for the analysis of skeleton human remains, and as a useful tool in the reconstruction of ancient events and bio-archaeological data in synergy with forensic sciences

Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo

In addition to intracellular calcium, which activates myosin light chain (MLC) kinase, MLC phosphorylation and hence contraction is importantly regulated by MLC phosphatase (MLCP). Recent evidence suggests that distinct signaling cascades of vasoactive hormones interact with the Rho/Rho kinase (ROK) pathway, affecting the activity of MLCP. The present study measured the impact of ROK inhibition on vascular F-actin distribution and on vasoconstriction induced by activation/inhibition of distinct signaling pathways in vivo in the microcirculation of the split hydronephrotic rat kidney. Local application of the ROK inhibitors Y-27632 or HA-1077 induced marked dilation of pre- and postglomerular vessels. Activation of phospholipase C with the endothelin ET B agonist IRL 1620, inhibition of soluble guanylyl cyclase with 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ), or inhibition of adenylyl cyclase with the adenosine A1 agonist N6-cyclopentyladenosine (CPA) reduced glomerular blood flow (GBF) by about 50% through vasoconstriction at different vascular levels. ROK inhibition with Y-27632 or HA-1077, but not protein kinase C inhibition with Ro 31-8220, blunted ET B-induced vasoconstriction. Furthermore, the reduction of GBF and of vascular diameters in response to ODQ or CPA were abolished by pretreatment with Y-27632. ROK inhibitors prevented constriction of preglomerular vessels and of efferent arterioles with equal effectiveness. Confocal microscopy demonstrated that Y-27632 did not change F-actin content and distribution in renal vessels. The results suggest that ROK inhibition might be considered as a potent treatment of renal vasoconstriction, because it interferes with constriction induced by distinct signaling pathways in renal vessels without affecting F-actin structure

Particle and light fragment emission in peripheral heavy ion collisions at Fermi energies

A systematic investigation of the average multiplicities of light charged particles and intermediate mass fragments emitted in peripheral and semiperipheral collisions is presented as a function of the beam energy, violence of the collision and mass of the system. The data have been collected with the "Fiasco" setup in the reactions 93Nb+93Nb at 17, 23, 30, 38AMeV and 116Sn+116Sn at 30, 38AMeV. The midvelocity emission has been separated from the emission of the projectile-like fragment. This last component appears to be compatible with an evaporation from an equilibrated source at normal density, as described by the statistical code Gemini at the appropriate excitation energy. On the contrary, the midvelocity emission presents remarkable differences for what concerns both the dependence of the multiplicities on the energy deposited in the midvelocity region and the isotopic composition of the emitted light charged particles.Comment: 18 pages, 17 figures, Revtex

Mortality and Morbidity Following Endovascular Repair of Abdominal Aortic Aneurysms: Analysis of Two Single Centre Experiences

AbstractObjective to show how differences in anatomical and physiological risk factors can affect the outcome of endovascular repair of AAA by describing the experience of two centres with different selection policies. Methods one hundred and thirty-five patients (group I) were treated at Queen's Medical Centre (Nottingham, U.K.) using 101 in-house made and 34 manufactured stent-grafts. Median diameter, length and angulation of the proximal aneurysm neck were 26 mm, 27 mm, 40°, respectively. Seventy-six patients had ischaemic heart disease, 47 had left ventricular failure, median forced expiratory volume in one second (FEV1) was 83%, median creatinine was 100 μmol/l and median age was 72 years. Fifty patients (group II) were treated at Timone Hospital (Marseilles, France) using seven in-house made and 43 manufactured stent-grafts. Median diameter, length and angulation of the proximal aneurysm neck were 25 mm, 34 mm, 33°, respectively. Thirteen patients had ischaemic heart disease, two had left ventricular failure, median forced expiratory volume in one second was 101%, median creatinine was 108 μmol/l and mean age was 72 years. Results anatomical characteristics of the proximal neck were significantly worse in group I (p=0.02 for the three variables). Cardiac comorbidities were more frequent and mean FEV1 was lower in group I (p<0.0001 and p=0.001, respectively. Median aneurysm diameter was significantly greater in group I (65 mm) than in group II (53 mm) (p<0.001). Postoperative mortality was 9% and 0% in groups I and II respectively (p=0.03). The incidence of technical complications (groin wound complications and side branches endoleaks being excluded) was 20% and 0% in groups I and II, respectively (p=0.0006). Conclusion postoperative mortality and technical complication rates were significantly greater in group I than in group II, readily explained by poorer general condition and worse anatomical characteristics of the proximal neck in group I

Mid-Pliocene shifts in ocean overturning circulation and the onset of Quaternary-style climates

A major tipping point of Earth&apos;s history occurred during the mid-Pliocene: the onset of major Northern-Hemisphere Glaciation (NHG) and of pronounced, Quaternary-style cycles of glacial-to-interglacial climates, that contrast with more uniform climates over most of the preceding Cenozoic and continue until today (Zachos et al., 2001). The severe deterioration of climate occurred in three steps between 3.2 Ma (warm MIS K3) and 2.7 Ma (glacial MIS G6/4) (Lisiecki and Raymo, 2005). Various models (sensu Driscoll and Haug, 1998) and paleoceanographic records (intercalibrated using orbital age control) suggest clear linkages between the onset of NHG and the three steps in the final closure of the Central American Seaways (CAS), deduced from rising salinity differences between Caribbean and the East Pacific. Each closing event led to an enhanced North Atlantic meridional overturning circulation and this strengthened the poleward transport of salt and heat (warmings of +2–3&amp;deg;C) (Bartoli et al., 2005). Also, the closing resulted in a slight rise in the poleward atmospheric moisture transport to northwestern Eurasia (Lunt et al., 2007), which probably led to an enhanced precipitation and fluvial run-off, lower sea surface salinity (SSS), and an increased sea-ice cover in the Arctic Ocean, hence promoting albedo and the build-up of continental ice sheets. Most important, new evidence shows that the closing of the CAS led to greater steric height of the North Pacific and thus doubled the low-saline Arctic Throughflow from the Bering Strait to the East Greenland Current (EGC). Accordingly, Labrador Sea IODP Site 1307 displays an abrupt but irreversible EGC cooling of 6&amp;deg;C and freshening by ~2 psu from 3.25/3.16–3.00 Ma, right after the first but still reversible attempt of closing the CAS

Repurposing Face Masks after Use: From Wastes to Anode Materials for Na-Ion Batteries

Nowadays, face masks play an essential role in limiting coronavirus diffusion. However, their disposable nature represents a relevant environmental issue. In this work, we propose the utilization of two types of disposed (waste) face masks to prepare hard carbons (biochar) by pyrolytic conversion in mild conditions. Moreover, we evaluated the application of the produced hard carbons as anode materials in Na-ion batteries. Pristine face masks were firstly analyzed through infrared spectroscopy and thermogravimetric analysis. The pyrolysis of both mask types resulted in highly disordered carbons, as revealed by field-emission scanning electron microscopy and Raman spectroscopy, with a very low specific surface area. Anodes prepared with these carbons were tested in laboratory-scale Na-metal cells through electrochemical impedance spectroscopy, cyclic voltammetry and galvanostatic cycling, displaying an acceptable specific capacity along a wide range of current regimes, with a good coulombic efficiency (>98% over at least 750 cycles). As a proof of concept, the anodes were also used to assemble a Na-ion cell in combination with a Na3V2(PO4)(2)F-3 (NVPF) cathode and tested towards galvanostatic cycling, with an initial capacity of almost 120 mAhg(-1) (decreasing at about 47 mAhg(-1) after 50 cycles). Even though further optimization is required for a real application, the achieved electrochemical performances represent a preliminary confirmation of the possibility of repurposing disposable face masks into higher-value materials for Na-ion batteries